Testapparatuur voor tabletten, poeders en capsules

Dissolution Testing

Dissolution is a test used by the Pharmaceutical industry to characterize the dissolution properties of the active drug, the active drug's release and the dissolution from a dosage formulation. Dissolution testing is used to formulate the drug dosage form and to develop quality control specifications for its manufacturing process. In-vitro dissolution testing is a critical test that has to correlate with in-vivo clinical studies and which could require specific method developments. Dissolution testing is described in many pharmacopeias, in EP, USP chapters and FDA guidelines.

USP 1, 2, 5, 6

Tablets are classically tested according to the USP 2 paddle method. Swelling or floating dosage forms such as capsules are tested according to USP 1 basket method. USP 5 (paddle-over-disk) and USP 6 (rotating cylinder) are used for transdermal dosage forms.

USP 4

To benefit from complete flexibility on media volumes and to reproducibly position dosage forms such as powders, APIs, lipophilic forms e.g. suppositories, suspensions, liposomes, microspheres, semi-solids, implants and medical devices e.g. drug eluting stents, the right method is the USP 4 flow-through cell.

ISO 9001

PMT Benelux NV/SAHaachtsesteenweg 378 bus 01 | 1910 KAMPENHOUT | BELGIE | Tel +32 (0)16 65 92 92 | Fax +32 (0)16 65 22 05 | e-mail info(at)pmtbenelux.com